Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine Graduate Programs in the Biomedical Sciences and Public Health
نویسندگان
چکیده
The prevalence of maternal smoking remains surprisingly high, ranging from 10-50% of pregnant women across different countries and socioeconomic groups. This is associated with several adverse neurological outcomes including increased risk for Sudden Infant Dealth Syndrome, attention deficit disorder, and autism. Prenatal exposure to carbon monoxide (CO), a major toxic constituent of cigarette smoke, disrupts development of diverse brain structures and associates with similar neurological disorders. While the global effects of CO on the developing brain have been studied, the specific effects of CO on neocortical development and neuronal migration have not. In the first set of experiments we determined if CO exposure resulted in structural changes of the neocortex. Pregnant mice (CD1) were exposed to different concentrations of CO approximating levels found in smokers (0 or 150 ppm) from embryonic day 7 (E7) until birth. Bromodeoxyuridine (BrdU) was injected on either E12 or E16 to map the distribution of neocortical cells born on that date. Neocortical cells born early during corticogenesis (E12) were abnormally distributed toward the upper layers
منابع مشابه
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE GRADUATE PROGRAMS IN T]ciE BIOMEDlCAL SCIENCES . AND PUBLIC HEALTH
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Uniformed Services University of the Health Science F. Edward Hebert School of Medicine Graduate Programs in the Biomedical Sciences and Public Health
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.................................................................................................................................................. II GLOSSARY OF TERMS............................................................................................................................IV TABLE OF CONTENTS ........................................................................................
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